Tuesday, June 10, 2008

28 - urea cycle

Reactions of cycle:

Step

Reactant

Product

Catalyzed by


1M

2ATP + HCO3- + NH4+

carbamoyl phosphate + 2ADP + Pi

CPS


2M

carbamoyl phosphate + ornithine

citrulline + Pi

OTC


3C

citrulline + aspartate + ATP

argininosuccinate + AMP + PPi

ASS


4C

argininosuccinate

Arg + fumarate

ASL


5C

Arg + H2O

ornithine + urea

ARG1



CPS1 stands for carbamoyl phosphate synthase 1 enzyme. OTC stands for ornithine transcarbamoylase. ASS stands for arginine succinate synthase. ASL stands for arginosuccinate lyase . ARG stands for arginase .the first two steps occur in mitochondria(M) and the next 3 steps occur in cytosol(C)

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